Evolving New Protein-Protein Interaction Specificity through Promiscuous Intermediates
نویسندگان
چکیده
منابع مشابه
Evolving New Protein-Protein Interaction Specificity through Promiscuous Intermediates
Interacting proteins typically coevolve, and the identification of coevolving amino acids can pinpoint residues required for interaction specificity. This approach often assumes that an interface-disrupting mutation in one protein drives selection of a compensatory mutation in its partner during evolution. However, this model requires a non-functional intermediate state prior to the compensator...
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ژورنال
عنوان ژورنال: Cell
سال: 2015
ISSN: 0092-8674
DOI: 10.1016/j.cell.2015.09.055